Fourth Edition
2000
by Eric R. Kandel
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Principles of Neural Science presents an in-depth summary of the state of the science as well as a full discussion of historical issues.
Neuroanatomy, cell and molecular mechanisms of signaling, development and plasticity are thoroughly described in the context of cognitive approaches to behavior.
Principles of Neural Science is an essential reference for your clinical practice or research.
This edition features expanded treatment of:
Ion channel mechanisms, including new structural views of both voltage-gated and transmitter-gated channels involved in neuronal signaling development of the nervous system-covering neuroinduction and patterning, the generation of cell lineages, cell-cell adhesion, axon outgrowth, target recognition, and synapse formation
The genetic basis of neurological and psychiatric diseases-Huntington's disease, Alzheimer's disease, muscular dystrophy, depression, and schizophrenia cognitive neuroscience of perception, planning, action, motivation, and memory
And the new, spectacular color art program reinforces basic concepts and principles with remarkable clarity. Principles of Neural Science, Fourth Edition provides the most current, comprehensive coverage of this exciting and fast-moving field.
Contents:
I.The Neurobiology of Behavior
1.The Brain and Behavior
2.Nerve Cells and Behavior
3.Genes and Behavior
II.Cell and Molecular Biology of the Neuron
4.The Cytology of Neurons
5.Synthesis and Trafficking of Neuronal Protein
6.Ion Channels
7.Membrane Potential
8.Local Signaling: Passive Electrical Properties of the Neuron
9.Propagated Signaling: The Action Potential
III.Elementary Interactions Between Neurons: Synaptic Transmission
10.Overview of Synaptic Transmission
11.Signaling at the Nerve-Muscle Synapse: Directly Gated Transmission
12.Synaptic Integration
13.Modulation of Synaptic Transmission: Second Messengers
14.Transmitter Release
15.Neurotransmitters
16.Diseases of Chemical Transmission at the Nerve-Muscle Synapse: Myasthenia Gravis
IV.The Neural Basis of Cognition
17.The Anatomical Organization of the Central Nervous System
18.The Functional Organization of Perception and Movement
19.Integration of Sensory and Motor Function: The Association Areas of the Cerebral Cortex and the Cognitive Capabilities of the Brain
20.From Nerve Cells to Cognition: The Internal Cellular Representation Required for Perception and Action
V.Perception
21.Coding of Sensory Information
22.The Bodily Senses
23.Touch
24.The Perception of Pain
25.Constructing the Visual Image
26.Visual Processing by the Retina
27.Central Visual Pathways
28.Perception of Motion, Depth, and Form
29.Color Vision
30.Hearing
31.Sensory Transduction in the Ear
32.Smell and Taste: The Chemical Senses
VI.Movement
33.The Organization of Movement
34.The Motor Unit and Muscle Action
35.Diseases of the Motor Unit
36.Spinal Reflexes
37.Locomotion
38.Voluntary Movement
39.The Control of Gaze
40.The Vestibular System
41.Posture
42.The Cerebellum
43.The Basal Ganglia
VII.Arousal, Emotion, and Behavior Homeostasis
44.Brain Stem, Reflexive Behavior, and the Cranial Nerves
45.Brain Stem Modulation of Sensation, Movement, and Consciousness
46.Seizures and Epilepsy
47.Sleep and Dreaming
48.Disorders of Sleep and Wakefulness
49.The Autonomic Nervous System and the Hypothalamus
50.Emotional States and Feelings
51.Motivational and Addictive States
VIII.The Development of the Nervous System
52.The Induction and Patterning of the Nervous System
53.The Generation and Survival of Nerve Cells
54.The Guidance of Axons to Their Targets
55.The Formation and Regeneration of Synapses
56.Sensory Experience and the Fine-Tuning of Synaptic Connections
57.Sexual Differentiation of the Nervous System
58.Aging of the Brain and Dementia of the Alzheimer Type
IX.Language, Thought, Mood, and Learning, and Memory
59.Language and the Aphasias
60.Disorders of Thought and Volition: Schizophrenia
61.Disorders of Mood: Depression, Mania, and Anxiety Disorders
62.Learning and Memory
63.Cellular Mechanisms of Learning and the Biological Basis of Individuality
Appendix A - Current Flow in Neurons
Appendix B - Ventricular Organization of Cerebrospinal Fluid: Blood-Brain Barrier, Brain Edema, and Hydrocephalus
Appendix C - Circulation of the Brain
Appendix D - Consciousness and the Neurobiology of the Twenty-First Century
Index














